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- Spacecraft naming
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- Spacelab
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- Spaceway F1
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- Stanley G. Love
- Stardust (spacecraft)
- Stephanie Wilson
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- Stephen Frick
- Stephen Robinson
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- Stephen Thorne (astronaut)
- Steve Bales
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- Steven Hawley
- Steven J. Dick
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- Steven Lindsey
- Steven R. Nagel
- Steven Smith (astronaut)
- Steven Swanson
- Story Musgrave
- Stratospheric Aerosol and Gas Experiment
- Stratospheric Observatory for Infrared Astronomy
- Stuart Roosa
- Sub-orbital spaceflight
- Subhash Saini
- Success-oriented management
- Sun
- Sunita Williams
- Supercritical airfoil
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- Surveyor 4
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- Susan G. Finley
- Susan Helms
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- Svalbard Satellite Station
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- Syncom
- Systems for Nuclear Auxiliary Power
- T. Jack Lee
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- TAOS
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- THEMIS
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- TechPort (NASA)
- TechSat-21
- Telemetry
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- Telstar
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- Terence T. Henricks
- Terra (satellite)
- Terrence W. Wilcutt
- Terry Hart
- Terry W. Virts
- Tethys (moon)
- Texas State Highway NASA Road 1
- Thad Roberts
- The Best of DreamWorks Pictures Columbia Pictures Revolution Studios Saturn Films Family Home Entertainment (2002)
- The Case of the Missing Moon Rocks
- The Challenger
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- Theodore Freeman
- Theodore Hancock
- Thermal and Evolved Gas Analyzer
- Thomas Akers
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- Thomas Marshburn
- Thomas McMurtry
- Thomas O. Paine
- Thomas P. Stafford
- Thomas Sever
- Thor-Agena
- Thor DSV-2U
- Timation
- Timeline of Ames Research Center
- Timeline of Mars Science Laboratory
- Timeline of STS-121
- Timothy Creamer
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- Titan (rocket family)
- Titan II GLV
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- Titan Mare Explorer
- Titan Saturn System Mission
- Titania (moon)
- Tom Davis (Cook Islands politician)
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- Total Ozone Mapping Spectrometer
- Total Solar Eclipse
- Tracy Caldwell Dyson
- Trailblazer (satellite)
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- Transit 3B
- Transit 5E-1
- Transit Research and Attitude Control
- Transiting Exoplanet Survey Satellite
- Triton (moon)
- Troll Satellite Station
- Tropical Rainfall Measuring Mission
- Trumpet (satellite)
- Twenty-Five-Foot Space Simulator
- U.S. Department of Defense
- U.S. Space & Rocket Center
- U.S. space exploration history on U.S. stamps
- UCISAT-1
- UFO (satellite)
- UFO Hunters
- UNAVCO
- USA-10
- USA-100
- USA-117
- USA-126
- USA-128
- USA-132
- USA-135
- USA-145
- USA-150
- USA-151
- USA-154
- USA-156
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